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1. What percentage of human blood is constituted by plasma?
A. 55%
B. 45%
C. 90%
D. 60%
Answer: A. 55%
Explanation: Plasma constitutes about 55% of the blood, while formed elements (RBCs, WBCs, platelets) make up the remaining 45%.
2. Which plasma protein is primarily responsible for osmotic balance in the blood?
A. Albumins
B. Globulins
C. Fibrinogen
D. Prothrombin
Answer: A. Albumins
Explanation: Albumins help maintain fluid and osmotic balance between blood vessels and tissues.
3. Which leukocyte is the most abundant type in human blood?
A. Neutrophils
B. Lymphocytes
C. Monocytes
D. Basophils
Answer: A. Neutrophils
Explanation: Neutrophils are the most abundant WBCs (60–65% of total WBC count) and act as phagocytic cells.
4. Which blood group is known as the universal donor?
A. O negative (O-ve)
B. AB positive (AB+ve)
C. A positive (A+ve)
D. B negative (B-ve)
Answer: A. O negative (O-ve)
Explanation: O negative blood lacks A, B, and Rh antigens, making it safe for transfusion to individuals of any blood group.
5. Erythroblastosis fetalis can occur when the mother is Rh-negative and the fetus is:
A. Rh-positive
B. Rh-negative
C. ABO incompatible
D. O negative
Answer: A. Rh-positive
Explanation: Rh incompatibility occurs when an Rh-negative mother carries an Rh-positive fetus, leading to maternal antibody formation against fetal RBCs in subsequent pregnancies.
6. The natural pacemaker of the human heart is the:
A. Sino-atrial node (SAN)
B. Atrio-ventricular node (AVN)
C. Bundle of His
D. Purkinje fibers
Answer: A. Sino-atrial node (SAN)
Explanation: The SAN generates maximum action potentials (70–75/min) and initiates and maintains rhythmic heart contraction.
7. In a normal ECG, the P-wave represents:
A. Depolarisation of the atria
B. Depolarisation of the ventricles
C. Repolarisation of the ventricles
D. Repolarisation of the atria
Answer: A. Depolarisation of the atria
Explanation: The P-wave represents electrical excitation (depolarisation) of atria, leading to atrial contraction.
8. The volume of blood pumped out by each ventricle during a single cardiac cycle is known as:
A. Stroke volume (~70 mL)
B. Cardiac output (~5000 mL)
C. Tidal volume (~500 mL)
D. End-diastolic volume (~120 mL)
Answer: A. Stroke volume (~70 mL)
Explanation: Each ventricle pumps out approximately 70 mL of blood per heartbeat, termed stroke volume.
9. The first heart sound ('Lub') is associated with the closure of:
A. Tricuspid and bicuspid (mitral) valves
B. Semilunar valves
C. Aortic valve only
D. Pulmonary valve only
Answer: A. Tricuspid and bicuspid (mitral) valves
Explanation: The first heart sound 'Lub' is produced by closure of atrioventricular (tricuspid and bicuspid) valves during ventricular systole.
10. Blood pressure higher than 140/90 mm Hg is clinically termed as:
A. Hypertension
B. Hypotension
C. Atherosclerosis
D. Angina pectoris
Answer: A. Hypertension
Explanation: Repeated readings of blood pressure at 140/90 mm Hg or higher indicate hypertension (high blood pressure).
11. Which blood vessel carries oxygenated blood from the lungs to the left atrium?
A. Pulmonary vein
B. Pulmonary artery
C. Superior vena cava
D. Aorta
Answer: A. Pulmonary vein
Explanation: Pulmonary veins carry oxygen-rich blood from lungs into the left atrium of the heart.
12. Which ion plays a critical role in the blood clotting cascade?
A. Calcium ions (Ca2+)
B. Sodium ions (Na+)
C. Potassium ions (K+)
D. Iron ions (Fe2+)
Answer: A. Calcium ions (Ca2+)
Explanation: Calcium ions play a mandatory role in multiple enzymatic steps of the blood coagulation cascade.
13. The middle muscular layer of the heart wall is called:
A. Myocardium
B. Epicardium
C. Endocardium
D. Pericardium
Answer: A. Myocardium
Explanation: The wall of the heart consists of three layers: outer epicardium, middle myocardium (cardiac muscle), and inner endocardium.
14. Formed elements produced from megakaryocytes in the bone marrow are:
A. Blood platelets (Thrombocytes)
B. Erythrocytes
C. Monocytes
D. Eosinophils
Answer: A. Blood platelets (Thrombocytes)
Explanation: Platelets are cell fragments produced from large specialized bone marrow cells called megakaryocytes.
15. Open circulatory system is found in which of the following animal groups?
A. Arthropods and Molluscs
B. Annelids and Chordates
C. Vertebrates and Cephalopods
D. Birds and Mammals
Answer: A. Arthropods and Molluscs
Explanation: Arthropods and non-cephalopod molluscs have an open circulatory system where blood flows into open spaces (hemocoel).
16. The hepatic portal system connects the digestive tract directly to the:
A. Liver
B. Kidney
C. Heart
D. Spleen
Answer: A. Liver
Explanation: The hepatic portal vein carries nutrient-rich blood from the digestive intestine to the liver before reaching systemic circulation.
17. Acute chest pain due to inadequate oxygen reaching the heart muscle is called:
A. Angina pectoris
B. Heart failure
C. Heart attack
D. Cardiac arrest
Answer: A. Angina pectoris
Explanation: Angina (or angina pectoris) is chest discomfort/pain when blood flow and oxygen to cardiac muscles are insufficient.
18. Bicuspid valve (mitral valve) guards the opening between:
A. Left atrium and left ventricle
B. Right atrium and right ventricle
C. Right ventricle and pulmonary artery
D. Left ventricle and aorta
Answer: A. Left atrium and left ventricle
Explanation: Bicuspid (mitral) valve guards left atrioventricular opening, while tricuspid valve guards right atrioventricular opening.
19. Neural signals through sympathetic nerves can increase heart rate by:
A. Increasing rate of heartbeat and strength of ventricular contraction
B. Decreasing heart rate and cardiac output
C. Blocking action potential generation at SAN
D. Dilating blood vessels exclusively
Answer: A. Increasing rate of heartbeat and strength of ventricular contraction
Explanation: Sympathetic nervous signals release adrenaline/noradrenaline, which speed up SA node discharge and cardiac muscle contractility.
20. Lymph differs from blood in that lymph lacks:
A. RBCs and larger plasma proteins
B. WBCs
C. Water
D. Glucose and nutrients
Answer: A. RBCs and larger plasma proteins
Explanation: Lymph is a colorless fluid filtered from blood capillaries into tissue spaces; it lacks erythrocytes and large plasma proteins.
21. The average lifespan of human Red Blood Cells (RBCs) is:
A. 120 days
B. 30 days
C. 7 days
D. 365 days
Answer: A. 120 days
Explanation: Human RBCs circulate in the bloodstream for about 120 days before being destroyed in the spleen.
22. Which organ is known as the graveyard of RBCs?
A. Spleen
B. Liver
C. Bone marrow
D. Kidney
Answer: A. Spleen
Explanation: Worn-out and senescent red blood cells are filtered out and broken down predominantly in the spleen.
23. Standard cardiac output of a resting adult human is approximately:
A. 5 Litres/minute
B. 2 Litres/minute
C. 10 Litres/minute
D. 1 Litre/minute
Answer: A. 5 Litres/minute
Explanation: Cardiac output = Stroke Volume (70 mL) × Heart Rate (72/min) ≈ 5000 mL or 5 L per minute.
24. In an ECG graph, the QRS complex represents:
A. Depolarisation of ventricles
B. Depolarisation of atria
C. Repolarisation of ventricles
D. Repolarisation of atria
Answer: A. Depolarisation of ventricles
Explanation: The QRS complex represents ventricular depolarisation, triggering ventricular contraction.
25. Granulocytes among white blood cells include:
A. Neutrophils, Eosinophils, Basophils
B. Lymphocytes and Monocytes
C. Monocytes and Neutrophils
D. Lymphocytes and Basophils
Answer: A. Neutrophils, Eosinophils, Basophils
Explanation: WBCs with cytoplasmic granules are classified as granulocytes (neutrophils, eosinophils, basophils).
26. Which type of WBC secretes histamine, serotonin, and heparin involved in inflammatory reactions?
A. Basophils
B. Neutrophils
C. Monocytes
D. Lymphocytes
Answer: A. Basophils
Explanation: Basophils constitute 0.5–1% of WBCs and secrete mediator molecules like histamine, serotonin, and heparin.
27. Human heart is described as myogenic because:
A. Heartbeat originates in specialized nodal muscle tissue
B. Heartbeat originates from external motor nerve impulses
C. Heart consists solely of smooth muscle
D. Heart rate is completely voluntary
Answer: A. Heartbeat originates in specialized nodal muscle tissue
Explanation: Human auto-excitable cardiac muscle (SAN) generates action potentials independently, making the human heart myogenic.
28. The second heart sound ('Dub') is caused by the closure of:
A. Semilunar valves
B. Atrioventricular valves
C. Tricuspid valve only
D. Bicuspid valve only
Answer: A. Semilunar valves
Explanation: 'Dub' sound occurs at the start of ventricular diastole due to closure of aortic and pulmonary semilunar valves.
29. Deposition of calcium, fat, cholesterol, and fibrous tissue in coronary arteries leads to:
A. Atherosclerosis (Coronary Artery Disease)
B. Heart failure
C. Rheumatic fever
D. Pulmonary hypertension
Answer: A. Atherosclerosis (Coronary Artery Disease)
Explanation: CAD/Atherosclerosis narrows the lumen of arteries supplying blood to heart muscles due to plaque buildup.
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